MiR-125b promotes migration and invasion by targeting the vitamin D receptor in renal cell carcinoma

Purpose: To investigate the expression of miR-125b and vitamin D receptor (VDR) in renal cell carcinoma (RCC) assess biological function RCC. Methods: We used quantitative real-time polymerase chain reaction (RT-PCR) to detect nucleic acids western blotting analyze protein abundance RCC lines. MiR-125b mimic inhibitor were employed behavior The relationship between miR-125 VDR was verified using luciferase assays. Results: Overexpression promoted migration invasion prevent apoptosis ACHN cells. In contrast, deficiency suppressed induced 786-O Luciferase assays indicated interaction VDR. collected samples, significantly higher tissues negatively correlated (r=-0.444, p=0.04). Conclusion: displays an oncogene profile RCC, patients with high should be a more frequent follow-up. MiR-125B may potential therapeutic target for